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Bioinformatics Option for Mathematics Majors

Goal Curriculum Sample Sequence Advisors

Purpose and Goals

     Within the advent of genomics and proteomics, the biological sciences are evolving from mainly experimental sciences performed at the bench to one in which large databases of information, probabilistic models and statistical analysis techniques play a significant role. Typical probabilistic models include variance components, hidden Markov models, Bayesian networks, and coalescent. Typical statistical methods include maximum likelihood, Bayesian inference, Monte Carlo Markov chains, and some methods of classification and clustering. Stochastic modeling and statistical methods are applied to a wide range of problems from Biology, such as mapping quantitative trait loci, analyzing gene expression data, sequence alignment, and reconstructing evolutionary trees. Thus, we propose a new option within the Mathematics major to provide students with a working knowledge of computing and biological sciences in order to pursue lead research in applied mathematical and statistical methodology.

    There is a need at Hunter College to prepare and train a new generation of mathematicians and statisticians capable of using computational analysis to solve important engineering problems arising from the new frontiers of biology and medicine at molecular level. The proposed curriculum will give Mathematics students the necessary background in Biology and Computer Science they need for a working understanding of the subject-matter, while putting a strong emphasis on a rigorous methodological training. These students will be well prepared for bioengineering careers in bioinformatics, the pharmaceutical industry, and the biotechnology industry. They will also be well prepared for graduate studies in the mathematics and statistics of bioinformatics.

Curriculum

     The major core courses will remain unchanged. They are currently as follows:

Major Entry Requirements – 9 credits

MATH 126 (1 cr.) or MATH 154 or Exam
MATH 150 (4 cr.) Calculus with Analytic Geometry I 
MATH 155 (4 cr.) Calculus with Analytic Geometry II

Major Core Curriculum – 21 credits

MATH 153 (0.5 cr.) Theoretical Calculus I Workshop
MATH 158 (0.5 cr.) Theoretical Calculus II Workshop
MATH 250 (4 cr.) Calculus with Analytic Geometry III
MATH 254 (3 cr.) Ordinary Differential Equations -or- MATH 255 Vector Analysis
MATH 260 (4 cr.) Linear Algebra
MATH 311 (3 cr.) Abstract Algebra I
MATH 351 (3 cr.) Mathematical Analysis I
STAT 213 (3 cr.) Introduction to Applied Statistics -or- STAT 311 Probability Theory 
 
     In order to pursue the Bioinformatics option (option 5), students are required to complete the following sequences, in addition to the core courses listed above:

Statistics Component – 6 credits

STAT 311 (3 cr.) Probability Theory -or- STAT 213 Intro. to Applied Statistics
STAT 319 (3 cr.) [New] Bayesian Inference in the Sciences  

Computing Component – 6 credits

CSCI 132 (3 cr.) [New] Practical UNIX and Programming
CSCI 232 (3 cr.) [New] Relational Database & SQL
 
Students will also take the following natural science courses, which will fulfill the
requirements for a minor in Biology or in Chemistry:  

Chemistry Component – 12 credits

CHEM 102-103 (4.5 cr.) General Chemistry I + Lab
CHEM 104-105 (4.5 cr.) General Chemistry II + Lab
CHEM 222 (3 cr.) Organic Chemistry
Note that CHEM 102-103 and CHEM 104-105 are GER/2/E courses. 
The GER/2/E block consists of at least 7 credits.

Biology Component– 12 credits

BIOL 100 (4.5 cr.) Principles of Biology I
BIOL 300* (4.5 cr.) Biological Chemistry -or- BIOL 302** Molecular Genetics
BIOL 425 (3 cr.) [New] Computational Molecular Biology
*BIOL 200 prerequisite is recommended but not required.
**BIOL 300 prerequisite is recommended but not required.


TOTAL CREDITS – 66 CREDITS 

Sample Course Sequence*

*Please see advisor for individualized course plans

Fall (Year 1) – 8.5 credits

GER/1/B: MATH 150
GER/2/E: CHEM 102-103
Spring (Year 1) – 8.5 credits

MATH 155
GER/2/E: CHEM 104-105
Fall (Year 2) – 9.5 credits

MATH 153/158   
MATH  250
BIOL 100
Spring (Year 2) – 10 credits        

MATH 254 or 255   
MATH 260   
STAT 213
Fall (Year 3) – 9 credits

MATH 351   
STAT 311
CSCI 132
Spring (Year 3) – 9 credits        

MATH 311
CHEM 222
CSCI 232 
Fall (Year 4) – 5 credits

BIOL 300   
STAT 319
Spring (Year 4) – 3 credits        

BIOL 425 

Faculty Advisors

  • Dr Makram Talih, 212-772-5308, makram.talih-at-hunter-dot-cuny-dot-edu
  • Dr Dana Draghicescu, 212-772-5748, dana.draghicescu-at-hunter-dot-cuny-dot-edu
©Hunter College
2007-2008
Document made with Nvu
Acknowledgments
National Institutes of Health (NIH)/MARC Program
Howard Hughes Medical Institute (HHMI)

Center for the Study of Gene Structure and Function